Strategies for Handling Spatial Uncertainty due to Discretization

Geographic information systems (GISs) allow users to analyze geographic phenomena within areas of interest that lead to an understanding of their relationships and thus provide a helpful tool in decision-making. Neglecting the inherent uncertainties in spatial representations may result in undesired misinterpretations. There are several sources of uncertainty contributing to the quality of spatial data within a GIS: imperfections (e.g., inaccuracy and imprecision) and effects of discretization. An example for discretization in the thematic domain is the chosen number of classes to represent a spatial phenomenon (e.g., air temperature). In order to improve the utility of a GIS an inclusion of a formal data quality model is essential. A data quality model stores, specifies, and handles the necessary data required to provide uncertainty information for GIS applications. This dissertation develops a data quality model that associates sources of uncertainty with units of information (e.g., measurement and coverage) in a GIS. The data quality model provides a basis to construct metrics dealing with different sources of uncertainty and to support tools for propagation and cross-propagation. Two specific metrics are developed that focus on two sources of uncertainty: inaccuracy and discretization. The first metric identifies a minimal?resolvable object size within a sampled field of a continuous variable. This metric, called detectability, is calculated as a spatially varying variable. The second metric, called reliability, investigates the effects of discretization on reliability. This metric estimates the variation of an underlying random variable and determines the reliability of a representation. It is also calculated as a spatially varying variable. Subsequently, this metric is used to assess the relationship between the influence of the number of sample points versus the influence of the degree of variation on the reliability of a representation. The results of this investigation show that the variation influences the reliability of a representation more than the number of sample points

Estimating exploitable stock biomass for the Maine green sea urchin (Strongylocentrotus droebachiensis) fishery using a spatial statistics approach

The objective of this study was to investigate the spatial patterns in green sea urchin (Strongylocentrotus droebachiensis) density off the coast of Maine, using data from a fishery-independent survey program, to estimate the exploitable biomass of this species. The dependence of sea urchin variables on the environment, the lack of stationarity, and the presence of discontinuities in the study area made intrinsic geostatistics inappropriate for the study; therefore, we used triangulated irregular networks (TINs) to characterize the large-scale patterns in sea urchin density. The resulting density surfaces were modified to include only areas of the appropriate substrate type and depth zone, and were used to calculate total biomass. Exploitable biomass was estimated by using two different sea urchin density threshold values, which made different assumptions about the fishing industry. We observed considerable spatial variability on both small and large scales, including large-scale patterns in sea urchin density related to depth and fishing pressure. We conclude that the TIN method provides a reasonable spatial approach for generating biomass estimates for a fishery unsuited to geostatistics, but we suggest further studies into uncertainty estimation and the selection of threshold density values

Ultrastable CO2 Laser Trapping of Lithium Fermions

We demonstrate an ultrastable CO2 laser trap that provides tight confinement of neutral atoms with negligible optical scattering and minimal laser-noise- induced heating. Using this method, fermionic 6Li atoms are stored in a 0.4 mK deep well with a 1/e trap lifetime of 300 sec, consistent with a background pressure of 10^(-11) Torr. To our knowledge, this is the longest storage time ever achieved with an all-optical trap, comparable to the best reported magnetic traps.Comment: 4 pages using REVTeX, 1 eps figur

“A Good Personal Scientific Relationship”: Philip Morris Scientists and the Chulabhorn Research Institute, Bangkok

Jeff Collin and Ross MacKenzie analyze tobacco industry documents and find that Philip Morris consultants were able to gain access to a Thai research institute that is a WHO Collaborating Centre

GWAS for urinary sodium and potassium excretion highlights pathways shared with cardiovascular traits

© 2019, The Author(s). Urinary sodium and potassium excretion are associated with blood pressure (BP) and cardiovascular disease (CVD). The exact biological link between these traits is yet to be elucidated. Here, we identify 50 loci for sodium and 13 for potassium excretion in a large-scale genome-wide association study (GWAS) on urinary sodium and potassium excretion using data from 446,237 individuals of European descent from the UK Biobank study. We extensively interrogate the results using multiple analyses such as Mendelian randomization, functional assessment, co localization, genetic risk score, and pathway analyses. We identify a shared genetic component between urinary sodium and potassium expression and cardiovascular traits. Ingenuity pathway analysis shows that urinary sodium and potassium excretion loci are over-represented in behavioural response to stimuli. Our study highlights pathways that are shared between urinary sodium and potassium excretion and cardiovascular traits